Prefrontal–hippocampal interaction during the encoding of new memories


Takehara-Nishiuchi K, Brain and Neuroscience Advances.


When you explain the content of a movie, would you describe every single detail of what happened, where, and when? Alternatively, would you focus on the crucial elements of the story? Both approaches are valid and may be used in parallel when our brains form memories of daily experiences. A brain area called the hippocampus forms a memory trace that captures ongoing events with their precise location and timing. At the same time, another brain area called the medial prefrontal cortex (mPFC) sorts the events based on their similarity and integrates them over time. By doing so, the mPFC forms a parallel memory trace that captures only the essential content of the experience. This idea will guide future research to uncover how we memorize relevant events in our lives effectively.


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