Lateral entorhinal cortex supports the development of prefrontal network activity that bridges temporally discontiguous stimuli

Xiaotian (Tag) Yu, Jessica Yu, Allison Choi, Kaori Takehara-Nishiuchi, Hippocampus.


Sitting at home on a cold and rainy day, a bright flash momentarily illuminates your entire room, you’ve seen this many times before and mentally you prepare for what’s about to come next. Then, as on cue, the loud cacophony of thunder bellows from above. Through countless experiences of this pairing, lightning then thunder, you’ve formed a temporal association between the bright flash and the loud roar that occurs moments later. The ability to form these temporal associations come naturally to many animals and is dependent on the proper functioning of the hippocampus, lateral entorhinal cortex (LEC), and medial prefrontal cortex (mPFC). In this current study, we have found that by shutting down the LEC, not only do we impair rat’s ability to form temporal associations, but also found that electrical brain oscillations within the mPFC were severely disrupted. These findings highlight the importance of the LEC in temporal associative learning and shows how inactivation of the LEC directly impacts neural activity in the mPFC. 


New discovery