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Brain and Behaviour Seminar

March 27th

4 PM

Dr. Lisa Topolnik

University of Laval

"Organisation and Behavioral Function of Hippocampal Disinhibitory Circuits"

Vasoactive intestinal peptide (VIP) expressing cells are key GABAergic inhibitory interneurons that enable disinhibition of pyramidal neurons. Across cortical circuits, VIP and calretinin co-expressing cells exhibit common developmental, molecular, anatomical, and physiological organisation, and target primarily the somatostatin-expressing interneurons. In this talk, I will discuss recent results that reveal the role of these key microcircuit regulatory modules, demonstrating a context- and experience-specific segregation of inhibition and disinhibition during spontaneous behavior. In addition, I will describe recent advances in our understanding of the inhibition/excitation dynamics during fear learning in hippocampal circuits and discuss how impairments in these microcircuit modules may lead to abnormal network activity in Alzheimer’s Disease. 

Hybrid, In-person in Psychology Lounge (4th floor, Sidney Smith Hall, 100 St. George St)

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