Brain and Behaviour Seminar
4 PM Hybrid, In-person: Psychology Lounge
Dr. Lisa Topolnik
“Organisation and Behavioral Function of Hippocampal Disinhibitory Circuits”
Abstract: Vasoactive intestinal peptide (VIP) expressing cells are key GABAergic inhibitory interneurons that enable disinhibition of pyramidal neurons. Across cortical circuits, VIP and calretinin co-expressing cells exhibit common developmental, molecular, anatomical, and physiological organisation, and target primarily the somatostatin-expressing interneurons. In this talk, I will discuss recent results that reveal the role of these key microcircuit regulatory modules, demonstrating a context- and experience-specific segregation of inhibition and disinhibition during spontaneous behavior. In addition, I will describe recent advances in our understanding of the inhibition/excitation dynamics during fear learning in hippocampal circuits and discuss how impairments in these microcircuit modules may lead to abnormal network activity in Alzheimer’s Disease.
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