2026

Margarian S, Chen Y, Waheed J, Rezaeimanesh P, Chiang VS, Takehara-Nishiuchi K (2026) Cost-effective, open-source, automated apparatus for testing transitive inference in mice. Scientific Reports, 16, 13071

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Du L, Yang M, Steenland H, Luo Z, Ovcjak A, Hu R, Sugita S, Takehara-Nishiuchi K, Milosevic L, and Feng Z-P (2026) The long-term impact of neonatal hypoxic-ischemic brain injury on neural dynamics in deep-layer retrosplenial cortex and hippocampus in mice. iScience, in press 

 

2025

Chen Y, Tu G, Zhang L, and Takehara-Nishiuchi K (2025) Graded remapping of prefrontal representations preserves a cumulative record of distinct events within a single environment. iScience 28(8): 113009. Press release

 

Tu G, Wen P, Halawa A, and Takehara-Nishiuchi K (2025) Acetylcholine modulates prefrontal outcome coding during threat learning under uncertainty. eLife 13: RP102986

 

2024

Sun Y, Takehara-Nishiuchi K. (2024) The medial prefrontal cortex leaves the hippocampus when it prepares for the future. Science Progress, 107(2): 368504241261833.

 

2023

Jarovi J, Pilkiw M, and Takehara-Nishiuchi K (2023) Prefrontal neuronal ensembles link prior knowledge with novel actions during flexible action selection. Cell Reports 42: 113492.

 

2022

Takehara-Nishiuchi K (2022) Flexibility of memory for future-oriented cognition. Current Opinion in Neurobiology 76:102622, invited review.

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Yu XT, Jambere F, Takehara-Nishiuchi K (2022) Prefrontal projections to the nucleus reuniens signal behavioral relevance of stimuli during associative learning. Scientific Report, 12(1): 11995.

 

Takehara-Nishiuchi K (2022) Neuronal code for episodic time in the lateral entorhinal cortex. Frontiers in Integrative Neuroscience, 16:899412, invited review

 

Tu G, Halawa A, Yu X, Gillman S, Takehara-Nishiuchi K (2022) Outcome-locked cholinergic signaling suppresses prefrontal encoding of stimulus associations. Journal of Neuroscience, 42:4202–4214.

 

Takehara-Nishiuchi K (2022) Neuronal ensemble dynamics in associative learning. Current Opinion in Neurobiology 73:102530, invited review.

 

Pilkiw M, Jarovi J, Takehara-Nishiuchi K (2022) Lateral entorhinal cortex suppresses drift in cortical memory representations. Journal of Neuroscience 42:1104–1118, featured in This Week in The Journal.

 

2021

Yu XT, Yu J, Choi A, Takehara-Nishiuchi K (2021) Lateral entorhinal cortex supports the development of prefrontal network activity that bridges temporally discontiguous stimuli. Hippocampus 31:1285–1299

 

Takehara-Nishiuchi K (2021) Neurobiology of systems memory consolidation. European Journal of Neuroscience 54:6850–6863, invited review.

 

Lidhar NK, Thakur A, David A-J, Takehara-Nishiuchi K, Insel N (2021) Multiple dimensions of social motivation in adult female degus, PLoS One, 16(4): e0250219.

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2020

Takehara-Nishiuchi K, Morrissey MD, Pilkiw M (2020) Prefrontal neural ensembles develop selective code for stimulus associations within minutes of novel experiences, Journal of Neurosci, 40(43): 8355-8366.

 

Takehara-Nishiuchi K, (2020) Prefrontal-hippocampal interaction during the encoding of new memories, Brain and Neuroscience Advances, 4: 1-10. Invited review.

 

Xing B, Morrissey MD, Takehara-Nishiuchi K, (2020) Distributed representations of temporal stimulus associations across regular-firing and fast-spiking neurons in rat medial prefrontal cortex, Journal of Neurophysiology, 123(1): 439-450. 

 

2018

Pilkiw M, Takehara-Nishiuchi K. (2018) Neural representations of temporal associations, Neurobiology of Learning and Memory, 153(Pt A): 57-70. invited review

 

Nouriziabari, SB, Sarkar S, Tanninen SE, Dayton R, Klein RL, Takehara-Nishiuchi K. (2018) ERP-based detection of brain pathology in rat models for preclinical Alzheimer’s disease. Journal of Alzheimers Disease Research, 63(2): 725-740.

 

Ljubojevic V, Luu P, Gill P, Beckett L-A, Takehara-Nishiuchi K, De Rosa E. (2018) Cholinergic modulation of frontoparietal cortical network dynamics supporting supramodal attention. Journal of Neuroscience, 38(16): 3988-4005.

 

2017

Xia F, Richards BA, Josselyn SA, Takehara-Nishiuchi K*, Frankland PW* (*, co-corresponding authors). (2017) Medial prefrontal cortex parvalbumin-positive interneurons modulate spindle-ripple coupling and fear memory consolidation, eLife, 6, e27868.

 

Pilkiw M, Insel N, Cui Y, Finney C, Morrissey MD, Takehara-Nishiuchi K. (2017) Phasic and tonic neuron ensemble codes for stimulus-environment conjunctions in the lateral entorhinal cortex, eLife, 6, e28611.  

 

Tanninen SE, Nouriziabari, SB, Morrissey MD, Bakir R, Dayton R, Klein RL, Takehara-Nishiuchi K. (2017) Entorhinal tau pathology induces a neuronal signature in preclinical stages of Alzheimer’s disease. Neurobiology of Aging, 58:151-162.

 

Lidhar N, Insel N, Dong Y, Takehara-Nishiuchi K. (2017) Observational fear learning in degus is correlated with temporal vocalization patterns. Behavoural Brain Research, 332:362-371.

 

Morrissey M, Insel N, Takehara-Nishiuchi K. (2017) Generalizable knowledge outweighs incidental details in prefrontal ensemble code over time. eLife, 6:e22177. Featured on more than 20 news websites, including Neuroscience News, ScienceDaily, and U of T Bulletin.

 

2016

Volle J, Yu XT, Sun H, Tanninen SE, Insel N, Takehara-Nishiuchi K. (2016) Enhancing prefrontal neuron excitability enables associative learning of temporally disparate events. Cell Reports, 15(11):2400-2410.

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2015

Tanninen SE, Yu XT, Giritharan T, Tran L, Bakir R, Volle J, Morrissey MD, and Takehara-Nishiuchi K. (2015) Cholinergic, but not NMDA, receptors in the lateral entorhinal cortex mediate acquisition in trace eyeblink conditioning. Hippocampus, 25(11), 36-45.

 

Weyand S, Takehara-Nishiuchi K, and Chau T. (2015) Exploring methodological frameworks for a mental task-based near-infrared spectroscopy brain-computer interface. Journal of Neuroscience Methods, 254, 36-45.

 

Weyand S, Schudlo L, Takehara-Nishiuchi K, and Chau T. (2015) Usability and performance-informed selection of personalized mental tasks for an online near-infrared spectroscopy brain-computer interface. Neurophotonics, 2(2), 025001.

 

Insel N, Pilkiw M, Nobrega JN, Hutchison WD, Takehara-Nishiuchi K, Hamani C. (2015) Chronic deep brain stimulation of the rat ventral medial prefrontal cortex disrupts hippocampal-prefrontal coherence. Experimental Neurology, 269, 1-7. 

 

Weyand S, Takehara-Nishiuchi K, and Chau T. (2015) Weaning off mental tasks to achieve voluntary self-regulatory control of a near-infrared spectroscopy brain-computer interface. IEEE Trans Neural Syst Rehabil Eng, 23(4):548-561.

 

2014

Nguyen R, Morrissey MD, Mahadevan V, Cajanding J, Woodin M, Yeomans J, Takehara-Nishiuchi K, and Kim JC. (2014) Parvalbumin and GAD65 interneuron inhibition in the ventral hippocampus induces distinct behavioral deficits relevant to schizophrenia. Journal of Neuroscience, 34(45), 14948-14960.Chosen for the cover illustration

 

Morrissey MD, Takehara-Nishiuchi K. (2014) Diversity of mnemonic functions within the entorhinal cortex: A meta-analysis of rodent behavioral studies. Neurobiology of Learning and Memory, S1074-7427(14) 00145, invited review

 

Takehara-Nishiuchi K. (2014) Entorhinal cortex and consolidated memory. Neuroscience Research, 84C:27-33, invited review

 

2013

Tanninen SE, Morrissey MD, Takehara-Nishiuchi K. (2013) Unilateral lateral entorhinal inactivation impairs memory expression in trace eyeblink conditioning. PLoS One, 8(12), e84543. 

 

Insel N, Takehara-Nishiuchi K (2013) The cortical structure of consolidated memory: a new hypothesis on the role of the cingulate-entorhinal cortical connection. Neurobiology of Learning and Memory, 106, 344-350. Invited review

 

Shearkhani O, Takehara-Nishiuchi K (2013) Coupling of prefrontal gamma amplitude and theta phase is strengthened in trace eyeblink conditioning. Neurobiology of Learning and Memory, 100, 117-126. Chosen for the cover illustration

 

Takehara-Nishiuchi K, Insel N, Hoang LT, Wagner Z, Olson K, Chawla MK, Burke SN, Barnes CA. (2013) Activation patterns in superficial layers of neocortex change between experiences independent of behavior, environment, or the hippocampus. Cerebral Cortex, 23(9), 2225-2234.

 

2012

Morrissey MD, Maal-Bared G, Brady S, Takehara-Nishiuchi K (2012) Functional dissociation within the entorhinal cortex for memory retrieval of an association between temporally discontinuous stimuli. Journal of Neuroscience, 32(16), 5356-5361. 

 

2011

Takehara-Nishiuchi K, Maal-Bared G, Morrissey MD (2011) Increased entorhinal-prefrontal theta synchronization parallels decreased entorhinal-hippocampal theta synchronization during learning and consolidation of associative memory. Frontier in Behavioral Neuroscience 5: 90, Commented by Vetere and Ammassari-Teule in Frontiers in Neuroscience.

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Relevant publications before 2009

Takehara-Nishiuchi K, McNaughton BL. (2008) Spontaneous changes of neocortical code for associative memory during consolidation. Science 322: 960-963, Featured in ScienceNow Daily

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Takehara-Nishiuchi K, Nakao K, Kawahara S, Matsuki N, Kirino Y. (2006) Systems consolidation requires postlearning activation of NMDA receptors in the medial prefrontal cortex in trace eyeblink conditioning. Journal of Neuroscience 26: 5049-5058.

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Takehara K, Kawahara S, Kirino Y (2003) Time-dependent reorganization of the brain components underlying memory retention in trace eyeblink conditioning. Journal of Neuroscience 23:9897-9905, Rated as “Recommended” in Faculty 1000.