New paper published in eLife

February 16, 2017



Many events in our lives resemble experiences we have had before, without being
identical to them. Whenever you attend a party, for example, you may well take along a gift, such as
a bottle of wine or a box of chocolates, but the gift will differ on each occasion. Psychologists
believe that as our memories for such events become older, the incidental details unique to each
event (such as the identity of the gift) are mostly forgotten. However, the common underlying
patterns (what parties are like in general) are retained. This allows us to accumulate knowledge to
guide our behavior in similar situations in the future.

Studies in rodents and people have shown that a region of the brain called the medial prefrontal
cortex stores long-term memories about experiences. But to what extent do neurons in this region
represent abstract generalized knowledge as opposed to the specific incidental details?
To find out, Morrissey et al. used hair-thin electrodes to record the activity of hundreds of cells in
the medial prefrontal cortex as rats performed a learning and memory task. The rats learned that
either a tone or a light signaled the delivery of a mild electric shock. Initially, cells in the medial
prefrontal cortex responded differently to the tone and to the light. However, after three weeks, the
cells began to show similar responses to both stimuli.


The medial prefrontal cortex activity had thus transitioned from representing incidental details
(tone versus light) to representing abstract relationships (stimulus predicts shock). This may relate to
how the brain extracts commonality across experiences. A lingering question is how cells in the
medial prefrontal cortex become selective for abstract relationships. We know that memories are
reactivated during sleep. Therefore, one possibility is that combined reactivation of different
experiences selectively strengthens memories for any features common to those experiences.


This paper is open access and available here.

Please reload

Featured Posts

CAN meeting

May 27, 2019

Please reload

Recent Posts

May 27, 2019

January 19, 2019

November 14, 2018

November 25, 2017

September 4, 2017

Please reload

Please reload

Search By Tags
Please reload

Follow Us
  • Facebook Basic Square
  • Twitter Basic Square
  • Google+ Basic Square